Controlled encapsulation of single-cells into monodisperse picolitre drops.

@article{Edd2008ControlledEO,
  title={Controlled encapsulation of single-cells into monodisperse picolitre drops.},
  author={Jon F. Edd and Dino Di Carlo and Katherine J. Humphry and Sarah K{\"o}ster and Daniel Irimia and David A Weitz and Mehmet Toner},
  journal={Lab on a chip},
  year={2008},
  volume={8 8},
  pages={1262-4}
}
Encapsulation of cells within picolitre-size monodisperse drops provides new means to perform quantitative biological studies on a single-cell basis for large cell populations. Variability in the number of cells per drop due to stochastic cell loading is a major barrier to these techniques. We overcome this limitation by evenly spacing cells as they travel within a high aspect-ratio microchannel; cells enter the drop generator with the frequency of drop formation. 

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