Controlled delivery of bioactive molecules into live cells using the bacterial mechanosensitive channel MscL


Bacterial mechanosensitive channels are some of the largest pores in nature. In particular, MscL, with a pore diameter >25 Å, allows passage of large organic ions and small proteins. Functional MscL reconstitution into lipids has been proposed for applications in vesicular-based drug release. Here we show that these channels can be functionally expressed in… (More)
DOI: 10.1038/ncomms1999


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