Controlled delivery of antisense oligonucleotides: a brief review of current strategies.

@article{Zhao2009ControlledDO,
  title={Controlled delivery of antisense oligonucleotides: a brief review of current strategies.},
  author={Xiubo Zhao and Fang Pan and C. M. Holt and Andrew L Lewis and Jian Ren Lu},
  journal={Expert opinion on drug delivery},
  year={2009},
  volume={6 7},
  pages={673-86}
}
Antisense therapy has been investigated extensively over the past two decades, either experimentally for gene functional research or clinically as therapeutic agents owing to the conceptual simplicity, ease of design and low cost. The concept of this therapeutic approach is promising because short antisense oligonucleotides (ASOs) can be delivered into target cells for specific hybridisation with target mRNA, resulting in the inhibition of the expression of pathogenic genes. However, the… CONTINUE READING