Controlled biosynthesis of neoviridogriseins, new homologues of viridogrisein. III. Production, structures and biological properties of neoviridogriseins I and III.

@article{Okumura1979ControlledBO,
  title={Controlled biosynthesis of neoviridogriseins, new homologues of viridogrisein. III. Production, structures and biological properties of neoviridogriseins I and III.},
  author={Yasushi Okumura and Tomoko Takei and Michiko Sakamoto and Tomoyuki Ishikura and Yasuo Fukagawa},
  journal={The Journal of antibiotics},
  year={1979},
  volume={32 10},
  pages={
          1002-10
        }
}
The high response of our isolate of Streptomyces griseoviridus was exploited to provoke the synthesis of new viridogrisein homologues by adding various amino acids to the culture medium in an attempt to replace the alanine, sarcosine, leucine and phenylsarcosine moieties of virdogrisein. Among the amino acids added, L- and DL-alpha-amino-n-butyric acid and L-methionine gave new TLC spots which we named neoviridogriseins I and III and neoviridogrisein VII, respectively. The structures of… 
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11 Citations

11 Citations

Controlled biosynthesis of neoviridogriseins, new homologues of viridogrisein. IV. In vitro synergism between neoviridogrisein II and the antibiotics of the mikamycin A group.
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Grividomycins I, II and III, new antibiotics of the streptogramin class from Streptomyces sp. HIL Y-8240155
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Mutasynthesis and Directed Biosynthesis for the Production of New Antibiotics
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Chromatographic isolation and characterization of streptogramin antibiotics
Nucleic acid independent synthesis of peptides.
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In this review, the concepts of enzymatic peptide elongation reactions which have been summarized earlier (Kleinkauf and Koischwitz 1978) are extended.
Biological variation of microbial metabolites by precursor-directed biosynthesis.
Hydroxyproline-Containing Proteins and Their Hydroxylations by Genetically Distinct Prolyl 4-Hydroxylases
Recent applications of mass spectrometry to antibiotic research
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Controlled biosynthesis of neoviridogriseins, new homologues of viridogrisein II. Production, biological properties and structure of neoviridogrisein II.
TLDR
It is shown that the isolate of Streptomyces griseoviridus, which produced three minor factors in addition to viridogrisein and griseviridin, was more sensitive to the addition of L-proline than the type culture of StrePTomycesgriseovIRidus (NRRL2427).
Controlled biosynthesis of neoviridogriseins, new homologues of viridogrisein. IV. In vitro synergism between neoviridogrisein II and the antibiotics of the mikamycin A group.
Neoviridogrisein II is a homologue of viridogrisein in which the hydroxyproline residue is replaced by proline. Neoviridogrisein II proved to be more active than the parent antibiotic against…
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