Controlled and cardiac-restricted overexpression of the arginine vasopressin V1A receptor causes reversible left ventricular dysfunction through Gαq-mediated cell signaling.

@article{Li2011ControlledAC,
  title={Controlled and cardiac-restricted overexpression of the arginine vasopressin V1A receptor causes reversible left ventricular dysfunction through Gαq-mediated cell signaling.},
  author={Xue Li and Tung O. Chan and Valerie D. Myers and Ibrul Chowdhury and Xue-Qian Zhang and Jianliang Song and Jin Zhang and Jocelyn A Andrel and Hajime Funakoshi and Jeffrey Robbins and Walter J Koch and Terry Hyslop and Joseph Y Cheung and Arthur M Feldman},
  journal={Circulation},
  year={2011},
  volume={124 5},
  pages={572-81}
}
BACKGROUND [Arg8]-vasopressin (AVP) activates 3 G-protein-coupled receptors: V1A, V2, and V1B. The AVP-V1A receptor is the primary AVP receptor in the heart; however, its role in cardiac homeostasis is controversial. To better understand AVP-mediated signaling in the heart, we created a transgenic mouse with controlled overexpression of the V1A receptor. METHODS AND RESULTS The V1A receptor transgene was placed under the control of the tetracycline-regulated, cardiac-specific α-myosin heavy… CONTINUE READING
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