Controlled adsorption and release of amoxicillin in GO/HA composite materials

  title={Controlled adsorption and release of amoxicillin in GO/HA composite materials},
  author={Othmane Khalifi Taghzouti and Khalil El Mabrouk and Meriame Bricha and Khalid Nouneh},
  journal={SN Applied Sciences},
Present work is aimed at preparing hybrid composites based on graphene oxide and hydroxyapatite as a matrix (GO/HA), which can be used as a template for drug delivery after chirurgical operation. Composite materials were synthesized through an in situ precipitation as simple and save-time method. The obtained materials were characterized using infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), thermogravimetric analysis (TGA), and X-ray diffraction (XRD). Hybrid materials were… 
Synthesis and characterization of mesoporous HA/GO nanocomposite in the presence of chitosan as a potential candidate for drug delivery
HA is a suitable material for the drug delivery due to its unique properties (including high biodegradation, bioactivity, and biocompatibility). Therefore, in recent years, many studies have been


Control of bisphosphonate release using hydroxyapatite granules.
Findings indicated that Bps-HAp composites could be locally administered as a drug delivery system to areas with bone resorption.
In situ synthesis and biocompatibility of nano hydroxyapatite on pristine and chitosan functionalized graphene oxide.
Graphene oxide and chitosan (CS) functionalized graphene oxide were introduced as templates to fabricate hydroxyapatite (HA) using a facile solution-based in situ synthesis method, and GO-HA and CS-GO-HA nanocomposites were successfully prepared for the first time.
Freeze-drying synthesis, characterization and in vitro bioactivity of chitosan/graphene oxide/hydroxyapatite nanocomposite
Polycrystalline and dispersed hydroxyapatite (HAP) nanoparticles were successfully prepared via a simple precipitation method with the aid of a new capping agent based on Schiff base compounds. After
Enhanced hydroxyapatite nanorods formation on graphene oxide nanocomposite as a potential candidate for protein adsorption, pH controlled release and an effective drug delivery platform for cancer therapy
Experimental results showed that the HAp/GO nanocomposite not only exhibited good biocompatibility but also acted as good carrier for antic cancer drugs, thereby greatly reducing the side effects of free anticancer drugs administered at high doses.
Simultaneous Reduction and Surface Functionalization of Graphene Oxide for Hydroxyapatite Mineralization
In this study, we present the synthesis of reduced graphene oxide/hydroxyapatite (RGO/HA) hybrid materials by an environmental-friendly route. Graphene oxide (GO) was first simultaneously reduced and
In vitro study of biocompatibility of a graphene composite with gold nanoparticles and hydroxyapatite on human osteoblasts
The presence of graphene in the substrate composition induced an increased level of intracellular osteopontin and cytoskeleton reorganization (actin‐F) depending on graphene concentration, suggesting cell activation, increased cellular adhesion and acquisition of a mechanosensorial osteocyte phenotype.