Controlled Systemic Absorption and Increased Anesthetic Effect of Bupivacaine Following Epidural Administration of Bupivacaine-Hydroxypropyl-β-Cyclodextrin Complex

@article{Frville1996ControlledSA,
  title={Controlled Systemic Absorption and Increased Anesthetic Effect of Bupivacaine Following Epidural Administration of Bupivacaine-Hydroxypropyl-β-Cyclodextrin Complex},
  author={Jean Christophe Fr{\'e}ville and Gilles Dollo and P. Le Corre and François Chevanne and Roger Le Verge},
  journal={Pharmaceutical Research},
  year={1996},
  volume={13},
  pages={1576-1580}
}
Purpose. To investigate the influence of complexation between bupivacaine and hydroxypropyl-β-cyclodextrin (HP-β-CD) on the systemic absorption and on the pharmacodynamic effect of bupivacaine following epidural administration in a rabbit model. Methods. Bupivacaine and bupivacaine-HP-β-CD complex were administered according to a randomized and cross-over design in six rabbits chronically instrumented with an epidural catheter. The plasma concentrations of bupivacaine and the duration and… CONTINUE READING

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