Controlled Release of IGF-1 and HGF from a Biodegradable Polyurethane Scaffold

  title={Controlled Release of IGF-1 and HGF from a Biodegradable Polyurethane Scaffold},
  author={Devin M. Nelson and Priya R. Baraniak and Zuwei Ma and Jianjun Guan and Neale S. Mason and William R Wagner},
  journal={Pharmaceutical Research},
Biodegradable elastomers, which can possess favorable mechanical properties and degradation rates for soft tissue engineering applications, are more recently being explored as depots for biomolecule delivery. The objective of this study was to synthesize and process biodegradable, elastomeric poly(ester urethane)urea (PEUU) scaffolds and to characterize their ability to incorporate and release bioactive insulin-like growth factor–1 (IGF-1) and hepatocyte growth factor (HGF). Porous PEUU… CONTINUE READING
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