Controlled Osteogenic Differentiation of Mouse Mesenchymal Stem Cells by Tetracycline-Controlled Transcriptional Activation of Amelogenin.

@article{Wang2015ControlledOD,
  title={Controlled Osteogenic Differentiation of Mouse Mesenchymal Stem Cells by Tetracycline-Controlled Transcriptional Activation of Amelogenin.},
  author={Fangfang Wang and Hiroko Okawa and Yuya Kamano and Kunimichi Niibe and Hiroki Kayashima and Thanaphum Osathanon and Prasit Pavasant and Makio Saeki and Hirofumi Yatani and Hiroshi Egusa},
  journal={PloS one},
  year={2015},
  volume={10 12},
  pages={e0145677}
}
Regenerative dental therapies for bone tissues rely on efficient targeting of endogenous and transplanted mesenchymal stem cells (MSCs) to guide bone formation. Amelogenin is the primary component of Emdogain, which is used to regenerate periodontal defects; however, the mechanisms underlying the therapeutic effects on alveolar bone remain unclear. The tetracycline (Tet)-dependent transcriptional regulatory system is a good candidate to investigate distinct roles of genes of interest during… CONTINUE READING