Controlled Evaluation of the Effects of Hyperbaric Oxygen Therapy on the Behavior of 16 Children with Autism Spectrum Disorders

@article{Jepson2011ControlledEO,
  title={Controlled Evaluation of the Effects of Hyperbaric Oxygen Therapy on the Behavior of 16 Children with Autism Spectrum Disorders},
  author={Bryan M. Jepson and Doreen Granpeesheh and Jonathan Tarbox and Melissa L. Olive and Carol Stott and Scott A. Braud and J. Helen Yoo and ANDREW J. Wakefield and Michael S. Allen},
  journal={Journal of Autism and Developmental Disorders},
  year={2011},
  volume={41},
  pages={575-588}
}
Hyperbaric oxygen therapy (HBOT) has been used to treat individuals with autism. However, few studies of its effectiveness have been completed. The current study examined the effects of 40 HBOT sessions at 24% oxygen at 1.3 ATA on 11 topographies of directly observed behavior. Five replications of multiple baselines were completed across a total of 16 participants with autism spectrum disorders. No consistent effects were observed across any group or within any individual participant… Expand

Paper Mentions

Blog Post
Interventional Clinical Trial
PURPOSE The purpose of this investigation is to evaluate the cognitive and behavioral effects of Hyperbaric Oxygenation Therapy in children who present with a diagnosis of… Expand
ConditionsAutism
InterventionDevice
Brief Report: Hyperbaric Oxygen Therapy (HBOT) in Children with Autism Spectrum Disorder: A Clinical Trial
TLDR
There is no evidence that HBOT affects cytokine levels or that cytokine Levels were associated with behavioral changes, and parent-completed measures of behavior improvements were related to HBOT. Expand
Is Hyperbaric Oxygen Therapy an Effective Treatment for Autism: A Review
TLDR
It is premature to call HBOT an effective treatment for Autism and ASD, but individuals clinically treated with HBOT outside the context of a RCT should have the effects of the therapy evaluated using rigorous single-subject designs. Expand
Hyperbaric oxygen therapy for children with autism spectrum disorder.
TLDR
Hyperbaric oxygen therapy provides a higher concentration of oxygen delivered in a chamber or tube containing higher than sea level atmospheric pressure, and there is no evidence to support the benefit of HBOT for children with ASD. Expand
Using hyperbaric oxygen for autism treatment: A review and discussion of literature.
TLDR
HBO2 should not be recommended for ASD treatment until more conclusive favorable results and long-term outcomes are demonstrated from well-designed controlled trials. Expand
Therapeutic use of hyperbaric oxygen therapy for children with autism spectrum disorder.
TLDR
This article reviews important publications regarding the physiologic and clinical influence of HBO on ASD and proposes that low pressure/ low oxygen concentration hyperbaric treatment can improve the clinical manifestations of autism. Expand
Hyperbaric oxygen treatment in autism spectrum disorders
TLDR
Most studies of HBOT in children with ASD examined changes in behaviors and reported improvements in several behavioral domains although many of these studies were not controlled, and HBOT had minimal adverse effects and was well tolerated. Expand
Hyperbaric oxygen therapy for people with autism spectrum disorder (ASD).
TLDR
There is no evidence that hyperbaric oxygen therapy improves core symptoms and associated symptoms of ASD, and given the absence of evidence of effectiveness and the limited biological plausibility and possible adverse effects, the need for future RCTs of hyperbarIC oxygen therapy must be carefully considered. Expand
Hyperbaric oxygen therapy for treatment of children with autism: a systematic review of randomized trials
TLDR
This study systematically reviews the current evidences for treating of autism with HBO therapy and concludes that sham-controlled studies with rigorous methodology are required in order to provide scientific evidence-based HBO therapy for autism treatment. Expand
Hyperbaric oxygen therapy for the treatment of children and youth with Autism Spectrum Disorders: An evidence-based systematic review
TLDR
Current evidence does not support Hyperbaric Oxygen Therapy (HBOT) as an effective treatment for children and youth with ASD. Expand
Evolution and Preliminary Testing of a Hyperoxic Therapy for Autism Spectrum Disorders
TLDR
A pilot study with five cases involving preteens and teenagers with autism was conducted using a normobaric form of hyperoxic treatment, called Microbaric® Oxygen Therapy (MBO2), and it appears that the outcomes of MBO2 for autism are permanent. Expand
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References

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Randomized trial of hyperbaric oxygen therapy for children with autism
Abstract Autism Spectrum Disorders (ASDs) are characterized by the presence of impaired development in social interaction and communication and the presence of a restricted repertoire of activity andExpand
Using Behavior Analysis to Examine the Outcomes of Unproven Therapies: An Evaluation of Hyperbaric Oxygen Therapy for Children with Autism
TLDR
The methods and results of a behavior analytic evaluation of hyperbaric oxygen therapy, an unproven intervention that has been growing in popularity over the past several years, are described. Expand
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TLDR
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TLDR
Children with autism who received hyperbaric treatment at 1.3 atm and 24% oxygen for 40 hourly sessions had significant improvements in overall functioning, receptive language, social interaction, eye contact, and sensory/cognitive awareness compared to children who received slightly pressurized room air. Expand
The effects of hyperbaric oxygen therapy on oxidative stress, inflammation, and symptoms in children with autism: an open-label pilot study
TLDR
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TLDR
It is hypothesized that Hyperbaric oxygen therapy (HBOT) will improve symptoms in autistic individuals and a retrospective case series is presented that supports this hypothesis. Expand
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TLDR
The majority of controlled trials could not show positive effects, and considering the state of affairs the authors cannot recommend the use of hyperbaric oxygen in the treatment of multiple sclerosis. Expand
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TLDR
In this study, hyperbaric oxygen did not improve the condition of children with cerebral palsy compared with slightly pressurised air, and improvement seen in both groups for all dimensions tested deserves further consideration. Expand
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TLDR
Both HBOT and pressurized room air resulted in improvements in motor function compared with baseline, and similar improvements were seen in the observational studies. Expand
Hyperbaric oxygen for multiple sclerosis. Review of controlled trials.
TLDR
The majority of controlled trials could not show positive effects, and considering the state of affairs the authors cannot recommend the use of hyperbaric oxygen in the treatment of multiple sclerosis. Expand
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