Controlled Drug Release through a Plasma Polymerized Tetramethylcyclo-tetrasiloxane Coating Barrier

@article{Osaki2012ControlledDR,
  title={Controlled Drug Release through a Plasma Polymerized Tetramethylcyclo-tetrasiloxane Coating Barrier},
  author={Shigemasa Osaki and Meng Chen and Paul O. Zamora},
  journal={Journal of Biomaterials Science, Polymer Edition},
  year={2012},
  volume={23},
  pages={483 - 496}
}
A plasma polymerized tetramethylcyclo-tetrasiloxane (TMCTS) coating was deposited onto a metallic biomaterial, 316 stainless steel, to control the release rate of drugs, including daunomycin, rapamycin and NPC-15199 (N-(9-fluorenylmethoxy-carbonyl)-leucine), from the substrate surface. The plasma-state polymerized TMCTS thin film was deposited in a vacuum plasma reactor operated at a radio-frequency of 13.56 MHz, and was highly adhesive to the stainless steel, providing a smooth and hard… 
Modified drug release using atmospheric pressure plasma deposited siloxane coatings
This pilot study evaluates the potential of atmospheric plasma polymerised coatings to modify the rate of drug release from polymeric substrates. The antibiotic rifampicin was deposited in a
Plasma treatment as an efficient tool for controlled drug release from polymeric materials: A review
Modified Polymer Surfaces: Biocompatibility and Cell Interactions
TLDR
The effect of the modifi ed surface of polymers by low temperature plasma on protein adsorption, initial adhesion and subsequent growth of endothelial cells or osteoblasts, and how those plasma surface modifi cation approaches can be used for improved biocompatibility of biomaterials and medical devices or implants are discussed.
Application of Low-Temperature Plasma Processes for Biomaterials
Physical plasma is defined as a gas in which part of the particles that make up the matter are present in ionized form. This is achieved by heating a gas leading to dissociation of the molecular
Strategies for Drug Encapsulation and Controlled Delivery Based on Vapor‐Phase Deposited Thin Films
Vapor‐phase deposition methods allow the synthesis and engineering of organic and inorganic thin films, with high control on the chemical composition, physical properties, and conformality. In this
Comparison of polymethylmethacrylate (PMMA), native calcium sulfate, and high porous calcium sulfate beads as gentamicin carriers and osteoblast attachment
TLDR
Results suggested that the HPCS beads improved local antibiotic delivery and improved h-OBs attachment and the increasing porosity of calcium sulfate beads might improve drug delivery capacity and enhance the antibiotic elution property.
Microparticles Formulation as a Targeting Drug Delivery System
TLDR
The ideal sustained release products should not only have a prolonged drug releasing function, but should also offer once or twice a day dose treatment and better control of therapeutic drug level to have fewer side effects and improved disease management.
Sustained drug release from an ultrathin hydrogel film
We reported a facile method to prepare camptothecin (CPT) loaded ultrathin hydrogel films based on a polymeric prodrug via layer by layer (LbL) thiol–ene “click” chemistry. Free camptothecin could be
...
...

References

SHOWING 1-10 OF 37 REFERENCES
Design of infection-resistant antibiotic-releasing polymers. II. Controlled release of antibiotics through a plasma-deposited thin film barrier.
  • C. KwokT. HorbettB. Ratner
  • Materials Science
    Journal of controlled release : official journal of the Controlled Release Society
  • 1999
Preparation and in vitro characterization of gentamycin-impregnated biodegradable beads suitable for treatment of osteomyelitis.
TLDR
The PLA system displays improved release kinetics relative to PMMA, is biodegradable, is unaltered by gas sterilization, can be used for a range of antibiotics, and can be manipulated without disintegration, all desirable properties for an implantable drug delivery system for the prevention or treatment of osteomyelitis.
Solvent, emulsifier and drug concentration factors in poly(D,L-lactic acid) microspheres containing hexamethylmelamine
TLDR
Biodegradable poly(D,L-lactic acid) (PLA) microspheres containing hexamethylmelamine (HMM) were developed for potential use in chemoembolization and intraperitoneal implantation and the rate of drug release depended on drug loading and particle size.
Photopolymerization of multilaminated poly(HEMA) hydrogels for controlled release.
  • S. LuK. Anseth
  • Materials Science, Engineering
    Journal of controlled release : official journal of the Controlled Release Society
  • 1999
Porous biodegradable microparticles for delivery of pentamidine.
Solid molecular dispersions of poorly water-soluble drugs in poly(2-hydroxyethyl methacrylate) hydrogels.
  • P. ZahediPing I. Lee
  • Materials Science
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
  • 2007
...
...