Controlled Delivery of Sonic Hedgehog Morphogen and Its Potential for Cardiac Repair

@inproceedings{Johnson2013ControlledDO,
  title={Controlled Delivery of Sonic Hedgehog Morphogen and Its Potential for Cardiac Repair},
  author={Noah Ray Johnson and Yadong Wang},
  booktitle={PloS one},
  year={2013}
}
The morphogen Sonic hedgehog (Shh) holds great promise for repair or regeneration of tissues suffering ischemic injury, however clinical translation is limited by its short half-life in the body. Here, we describe a coacervate delivery system which incorporates Shh, protects it from degradation, and sustains its release for at least 3 weeks. Shh released from the coacervate stimulates cardiac fibroblasts to upregulate the expression of multiple trophic factors including VEGF, SDF-1α, IGF-1, and… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 49 references

Injectable fibroblast growth factor-2 coacervate for persistent angiogenesis.

Proceedings of the National Academy of Sciences of the United States of America • 2011
View 11 Excerpts
Highly Influenced

Design, synthesis, and biocompatibility of an arginine-based polyester.

Biotechnology progress • 2012
View 3 Excerpts
Highly Influenced

Controlled delivery of heparin-binding EGF-like growth factor yields fast and comprehensive wound healing.

Journal of controlled release : official journal of the Controlled Release Society • 2013
View 1 Excerpt