Controlled Cortical Impact and Craniotomy Induce Strikingly Similar Profiles of Inflammatory Gene Expression, but with Distinct Kinetics

@inproceedings{Lagraoui2012ControlledCI,
  title={Controlled Cortical Impact and Craniotomy Induce Strikingly Similar Profiles of Inflammatory Gene Expression, but with Distinct Kinetics},
  author={Mouna Lagraoui and Joseph R. Latoche and Natalia G. Cartwright and Gauthaman Sukumar and Clifton Lee Dalgard and Brian C. Schaefer},
  booktitle={Front. Neur.},
  year={2012}
}
An immediate consequence of traumatic brain injury (TBI) is the induction of an inflammatory response. Mounting data suggest that inflammation is a major contributor to TBI-induced brain damage. However, much remains unknown regarding the induction and regulation of the inflammatory response to TBI. In this study we compared the TBI-induced inflammatory response to severe parenchymal injury (controlled cortical impact) vs. mild brain injury (craniotomy) over a 21-day period. Our data show that… CONTINUE READING
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