Controlled Apoptosis by a Thermally Toggled Nanoscale Amplifier of Cellular Uptake

@inproceedings{MacEwan2014ControlledAB,
  title={Controlled Apoptosis by a Thermally Toggled Nanoscale
Amplifier of Cellular Uptake},
  author={Sarah R MacEwan and Ashutosh Chilkoti},
  booktitle={Nano letters},
  year={2014}
}
Internalization into cancer cells is a significant challenge in the delivery of many anticancer therapeutics. Drug carriers can address this challenge by facilitating cellular uptake of cytotoxic cargo in the tumor, while preventing cellular uptake in healthy tissues. Here we describe an extrinsically controlled drug carrier, a nanopeptifier, that amplifies cellular uptake by modulating the activity of cell-penetrating peptides with thermally toggled self-assembly of a genetically encoded… CONTINUE READING
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Nature reviews. Molecular cell biology

M. Sattler, H. Liang, +9 authors S. W. Fesik
  • Science
  • 2010