Control systems and decision making for antibody production

  title={Control systems and decision making for antibody production},
  author={Christopher C Goodnow and Carola G. Vinuesa and Katrina L Randall and Fabienne Mackay and Robert Brink},
  journal={Nature Immunology},
This paper synthesizes recent progress toward understanding the integrated control systems and fail-safes that guide the quality and quantity of antibody produced by B cells. We focus on four key decisions: (1) the choice between proliferation or death in perifollicular B cells in the first 3 days after antigen encounter; (2) differentiation of… CONTINUE READING