Control points in early T-cell development.

  title={Control points in early T-cell development.},
  author={Dale I Godfrey and Albert Zlotnik},
  journal={Immunology today},
  volume={14 11},
Intrathymic T-cell differentiation involves the generation, expansion and selection of distinct T-lymphocyte subsets. While positive and negative selection have been a focal point of T-cell development, these events represent the final stages in a complicated sequence of differentiation steps. Here, Dale Godfrey and Albert Zlotnik summarize recent advances in our understanding of early T-cell development and describe five 'control points' that identify key events in this sequence. 

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