Control of white-opaque phenotypic switching in Candida albicans by the Efg1p morphogenetic regulator.

@article{Sonneborn1999ControlOW,
  title={Control of white-opaque phenotypic switching in Candida albicans by the Efg1p morphogenetic regulator.},
  author={A Sonneborn and Bernd Tebarth and J. F. Ernst},
  journal={Infection and immunity},
  year={1999},
  volume={67 9},
  pages={4655-60}
}
Phenotypic switching in Candida albicans spontaneously generates different cellular morphologies and is manifested in strain WO-1 by the reversible switching between the white and opaque phenotypes. We present evidence that phenotypic switching is regulated by the Efg1 protein, which is known as an essential element of hyphal development (dimorphism). Firstly, EFG1 is expressed specifically in cells of the white but not the opaque phenotype. During mass conversion from the opaque to the white… CONTINUE READING

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