Control of virus reactivation arrests pulmonary herpesvirus-induced fibrosis in IFN-gamma receptor-deficient mice.

@article{Mora2007ControlOV,
  title={Control of virus reactivation arrests pulmonary herpesvirus-induced fibrosis in IFN-gamma receptor-deficient mice.},
  author={Ana L Mora and Edilson Torres-Gonz{\'a}lez and M. Diaz de Rojas and Jian-guo Xu and Jeffrey D Ritzenthaler and Samuel H Speck and Jesse Roman and Kenneth L. Brigham and Arlene A. Stecenko},
  journal={American journal of respiratory and critical care medicine},
  year={2007},
  volume={175 11},
  pages={1139-50}
}
RATIONALE Idiopathic pulmonary fibrosis (IPF) is a chronic progressive fibrotic lung disorder of unknown cause. Several studies suggest an association between Epstein-Barr virus pulmonary infection and the development of IPF. OBJECTIVES To determine whether reduction of gamma-herpesvirus reactivation from latency would alter progressive lung fibrogenesis in an animal model of virus-induced pulmonary fibrosis. METHODS IFN-gamma receptor-deficient (IFN-gammaR(-/-)) mice infected intranasally… CONTINUE READING