Control of urinary bladder smooth muscle excitability by the TRPM4 channel modulator 9-phenanthrol.

@article{Parajuli2013ControlOU,
  title={Control of urinary bladder smooth muscle excitability by the TRPM4 channel modulator 9-phenanthrol.},
  author={Shankar Prasad Parajuli and Kiril L. Hristov and Michelle N. Sullivan and Wenkuan Xin and Amy C Smith and Scott Earley and John Malysz and Georgi V Petkov},
  journal={Channels},
  year={2013},
  volume={7 6},
  pages={537-40}
}
The Ca (2+)-activated monovalent cation selective transient receptor potential melastatin 4 (TRPM4) channel has been recently identified in detrusor smooth muscle (DSM) of the urinary bladder. Two recent publications by our research group provide evidence in support of the novel hypothesis that TRPM4 channels enhance DSM excitability and contractility. This is a critical question as prior studies have primarily targeted hyperpolarizing currents facilitated by K(+) channels, but the depolarizing… CONTINUE READING