Control of tylosin biosynthesis in Streptomyces fradiae.

  title={Control of tylosin biosynthesis in Streptomyces fradiae.},
  author={Eric Cundliffe},
  journal={Journal of microbiology and biotechnology},
  volume={18 9},
  • Eric Cundliffe
  • Published 2008 in Journal of microbiology and biotechnology
Tylosin biosynthesis is controlled in cascade fashion by multiple transcriptional regulators, acting positively or negatively, in conjunction with a signalling ligand that acts as a classical inducer. The roles of regulatory gene products have been characterized by a combination of gene expression analysis and fermentation studies, using engineered strains of S. fradiae in which specific genes were inactivated or overexpressed. Among various novel features of the regulatory model, involvement… CONTINUE READING