Control of transplant tolerance and intragraft regulatory T cell localization by myeloid-derived suppressor cells and CCL5.

@article{Dilek2012ControlOT,
  title={Control of transplant tolerance and intragraft regulatory T cell localization by myeloid-derived suppressor cells and CCL5.},
  author={Nahzli Dilek and Nicolas Poirier and Claire Usal and Bernard Martinet and Gilles Blancho and Bernard Vanhove},
  journal={Journal of immunology},
  year={2012},
  volume={188 9},
  pages={4209-16}
}
Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immature cells that are believed to inhibit immune responses in the contexts of cancer and organ transplantation, in association with regulatory T cells (Treg). However, the way in which MDSC cooperate with Treg remains elusive. In this study, we used DNA microarrays to analyze gene expression in blood-derived MDSC from rat recipients of kidney allografts. We found CCL5 (Rantes), a chemotactic C-C motif 5 chemokine, to be… CONTINUE READING