Control of translation initiation in animals.

  title={Control of translation initiation in animals.},
  author={Nicola K Gray and Marvin P. Wickens},
  journal={Annual review of cell and developmental biology},
  • N. GrayM. Wickens
  • Published 1998
  • Biology
  • Annual review of cell and developmental biology
Regulation of translation initiation is a central control point in animal cells. We review our current understanding of the mechanisms of regulation, drawing particularly on examples in which the biological consequences of the regulation are clear. Specific mRNAs can be controlled via sequences in their 5' and 3' untranslated regions (UTRs) and by alterations in the translation machinery. The 5'UTR sequence can determine which initiation pathway is used to bring the ribosome to the initiation… 

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  • 1996
This review aims to assess recent progress in structure and function of initiation factors, physiological regulation of initiation factor activities and identification of features in the 5' and 3' untranslated regions of messenger RNA molecules that regulate the selection of these mRNAs for translation.

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