Control of translation initiation: a model-based analysis from limited experimental data.

@article{Dimelow2009ControlOT,
  title={Control of translation initiation: a model-based analysis from limited experimental data.},
  author={Richard J. Dimelow and Stephen J. Wilkinson},
  journal={Journal of the Royal Society, Interface},
  year={2009},
  volume={6 30},
  pages={51-61}
}
We have built a detailed kinetic model of translation initiation in yeast and have used a novel approach to determine the flux controlling steps based on limited experimental data. An efficient parameter estimation method was adapted in order to fit the most uncertain parameters (rate constants) to in vivo measurements in yeast. However, it was found that there were many other sets of plausible parameter values that also gave a good fit of the model to the data. We therefore used random… CONTINUE READING
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