Control of tissue manganese: initial absence and sudden emergence of excretion in the neonatal mouse.

@article{Miller1975ControlOT,
  title={Control of tissue manganese: initial absence and sudden emergence of excretion in the neonatal mouse.},
  author={Stephen T. Miller and George C. Cotzias and H A Evert},
  journal={The American journal of physiology},
  year={1975},
  volume={229 4},
  pages={1080-4}
}
All adult animals and humans tested up to this time have controlled their tissue manganese concentrations by controlling primarily the rate of the metal's excretion. In sharp contrast, neonatal mice did not excrete manganese for the first 17-18 days of life, although absorption of the natural 55Mn as well as distribution, tissue accumulation, and mitochondrial accumulation of the radioactive 54Mn were vigorous. This suggested as initially avid accumulation of this essential micronutrient… CONTINUE READING