Control of the selectivity of the aquaporin water channel family by global orientational tuning.

@article{Tajkhorshid2002ControlOT,
  title={Control of the selectivity of the aquaporin water channel family by global orientational tuning.},
  author={Emad Tajkhorshid and Peter Nollert and Morten \O. Jensen and Larry J. W. Miercke and Joseph O'Connell and Robert Michael Stroud and Klaus Schulten},
  journal={Science},
  year={2002},
  volume={296 5567},
  pages={525-30}
}
Aquaporins are transmembrane channels found in cell membranes of all life forms. We examine their apparently paradoxical property, facilitation of efficient permeation of water while excluding protons, which is of critical importance to preserving the electrochemical potential across the cell membrane. We have determined the structure of the Escherichia coli aquaglyceroporin GlpF with bound water, in native (2.7 angstroms) and in W48F/F200T mutant (2.1 angstroms) forms, and carried out 12… CONTINUE READING
Highly Influential
This paper has highly influenced 15 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 178 extracted citations

The structureof aquaporins

View 8 Excerpts
Highly Influenced

Symmetry, Selectivity, and the 2003 Nobel Prize

Cell • 2003
View 7 Excerpts
Highly Influenced

References

Publications referenced by this paper.

J . B . Heymann , A . Engel , News Physiol . Sci

G. Calamita, P. C. Maloney, P. Agre
J . Mol . Biol . • 1999

Similar Papers

Loading similar papers…