Control of the rhesus monkey menstrual cycle: permissive role of hypothalamic gonadotropin-releasing hormone.

@article{Knobil1980ControlOT,
  title={Control of the rhesus monkey menstrual cycle: permissive role of hypothalamic gonadotropin-releasing hormone.},
  author={Ernst Knobil and Tony M. Plant and Ludwig Wildt and Paul E Belchetz and G. Marshall},
  journal={Science},
  year={1980},
  volume={207 4437},
  pages={1371-3}
}
In rhesus monkeys with hypothalamic lesions (which appear to abolish the endogenous production of gonadotropin-releasing hormone), normal ovulatory mestrual cycles were reestablished by an unvarying, long-term replacement regimen consisting of one intravenous pulse of synthetic gonadotropic-releasing hormone per hour. This finding is in accord with the hypothesis that the pattern of pituitary gonadotropin secretion throughout the menstrual cycle (basal secretion interrupted, once every 28 days… CONTINUE READING

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