Control of the nuclear localization of Extradenticle by competing nuclear import and export signals.

@article{AbuShaar1999ControlOT,
  title={Control of the nuclear localization of Extradenticle by competing nuclear import and export signals.},
  author={M. Abu-Shaar and H. Ryoo and R. Mann},
  journal={Genes \& development},
  year={1999},
  volume={13 8},
  pages={
          935-45
        }
}
The Drosophila PBC protein Extradenticle (Exd) is regulated at the level of its subcellular distribution: It is cytoplasmic in the absence of Homothorax (Hth), a Meis family member, and nuclear in the presence of Hth. Here we present evidence that, in the absence of Hth, Exd is exported from nuclei due to the activity of a nuclear export signal (NES). The activity of this NES is inhibited by the antibiotic Leptomycin B, suggesting that Exd is exported by a CRM1/exportin1-related export pathway… Expand
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Nuclear targeting signal recognition: a key control point in nuclear transport?
  • D. Jans, C. Xiao, M. H. Lam
  • Biology, Medicine
  • BioEssays : news and reviews in molecular, cellular and developmental biology
  • 2000
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