• Corpus ID: 36871936

Control of the migratory pathway of facial branchiomotor neurones.

@article{Garel2000ControlOT,
  title={Control of the migratory pathway of facial branchiomotor neurones.},
  author={Sonia Garel and Mario Garc{\'i}a-Dom{\'i}nguez and Patrick Charnay},
  journal={Development},
  year={2000},
  volume={127 24},
  pages={
          5297-307
        }
}
Facial branchiomotor (fbm) neurones undergo a complex migration in the segmented mouse hindbrain. They are born in the basal plate of rhombomere (r) 4, migrate caudally through r5, and then dorsally and radially in r6. To study how migrating cells adapt to their changing environment and control their pathway, we have analysed this stereotyped migration in wild-type and mutant backgrounds. We show that during their migration, fbm neurones regulate the expression of genes encoding the cell… 
Initiation of facial motoneurone migration is dependent on rhombomeres 5 and 6.
TLDR
It is shown that chick FBM neurones are competent to recapitulate a migratory behaviour that has been lost during avian phylogeny, and this study takes advantage of the evolutionary migratory difference between mouse and chick in generating mouse-chick chimaeras in ovo.
Axon tracts guide zebrafish facial branchiomotor neuron migration through the hindbrain
TLDR
It is reported that ablation of either the cell body or the trailing axon of the leading FBMN, or ‘pioneer’ neuron, blocks the migration of follower F BMNs into r5, demonstrating that the pioneer neuron and its axon are crucial to the early migration of FBMNs.
Atypical Cadherins Celsr1-3 Differentially Regulate Migration of Facial Branchiomotor Neurons in Mice
TLDR
Analysis of the role of cadherins Celsr1-3, and Fzd3 in FBM neuron migration in mice indicates that CelsR1-2 and 3 differentially regulate F BM neuron migration.
Mouse Hindbrain Ex Vivo Culture to Study Facial Branchiomotor Neuron Migration
TLDR
This work provides a detailed protocol for wholemount ex vivo culture of mouse embryo hindbrains suitable to investigate the signaling pathways that regulate FBM migration and exposes neurons to function-blocking antibodies and small molecules in the culture media.
olig2‐expressing hindbrain cells are required for migrating facial motor neurons
TLDR
It is found that olig2 function is required for facial motor neurons to complete their caudal migration into r6 and r7 and form stereotypical clusters, and embryos that lack mafba function lack olig2 expression in r5 and r6.
Nkx6.1 controls migration and axon pathfinding of cranial branchio-motoneurons
TLDR
A requirement for Nkx6.1 in the development of postmitotic motoneurons is demonstrated, and a cell-autonomous function in the control of branchio-motoneuron migration is suggested.
Rest represses maturation within migrating facial branchiomotor neurons.
Dual roles of zygotic and maternal Scribble1 in neural migration and convergent extension movements in zebrafish embryos
TLDR
It is found that maternal expression of scrb1 is required for convergent extension (CE) movements during gastrulation and a genetic interaction between scrb 1 and trilobite(tri)/strabismus(stbm) in CE.
Robo1 and 2 repellent receptors cooperate to guide facial neuron cell migration and axon projections in the embryonic mouse hindbrain
TLDR
Robo1 and Robo2 have redundant functions to guide multiple aspects of the complex cell migration of the facial nucleus, as well as regulating axon trajectories and suppressing formation of ectopic axons.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 61 REFERENCES
Altered segmental identity and abnormal migration of motor neurons in mice lacking Hoxb-1
TLDR
It is demonstrated that, as a part of its role in maintaining rhombomere identity, Hoxb-1 is involved in controlling migratory properties of motor neurons in the hindbrain.
Rhombomere‐specific origin of branchial and visceral motoneurons of the facial nerve in the rat embryo
TLDR
The findings presented here show that most branchial and visceral motoneurons of the facial nerve are born in different and specific rhombomeres and Interestingly, developmental genes are expressed specifically in these rhombomes and could be involved in the genesis of the Facial and superior salivatory nuclei.
Floor Plate and Netrin-1 Are Involved in the Migration and Survival of Inferior Olivary Neurons
TLDR
A requirement for netrin-1, either directly or indirectly, for the survival of inferior olivary neurons is established and it is suggested that it may function as a specific guidance cue for the initial steps of the migration from the rhombic lips and then later in the development of the normal crossed projection of the inferior o Olivary neurons.
Organization and Development of Facial Motor Neurons in the Kreisler Mutant Mouse
TLDR
It is confirmed that rhombomeres are critical to hindbrain development and that they are the fundamental unit at which motor neurons are specified.
The role of kreisler in segmentation during hindbrain development.
TLDR
It is found that while r5 fails to form in these mice, r6 is present, which suggests that the formation of r6 has not been affected in kreisler mutants, and regulates multiple steps in segmental patterning involving both theformation of segments and their A-P identity.
Control of hindbrain motor neuron differentiation by the homeobox gene Phox2b.
TLDR
Genetic evidence is provided that the paired-like homeodomain protein Phox2b is required for the formation of all branchial and visceral, but not somatic, motor neurons in the hindbrain, which exemplifies a novel control point in the generation of CNS neurons.
Altered rhombomere-specific gene expression and hyoid bone differentiation in the mouse segmentation mutant, kreisler (kr).
TLDR
The hyoid bone in kr/kr animals exhibited an accessory process on the greater horn most easily explained by ectopic development of a second arch structure (the hyoid lesser horn) in an area normally derived from the third arch.
Persistence of rhombomeric organisation in the postsegmental hindbrain.
TLDR
Observations suggest that rhombomeres do not disappear at E5, as has previously been supposed, rather they persist in the ventricular zone to at least E9, ensuring a continuity in the presumed segmental cues that specify neuroepithelial cells in the hindbrain.
Segmental and neuronal architecture of the hindbrain of Krox-20 mouse mutants.
TLDR
It is concluded that r3 and r5 and their derivatives are completely eliminated in Krox-20(-/-) embryos while overall hindbrain segmentation is maintained and that the disappearance of these territories has important consequences for even-numbered rhombomeres as well.
Segment-specific expression of a homoeobox-containing gene in the mouse hindbrain
TLDR
It is reported that a mouse homoeobox-containing gene, Hox-2.9, is expressed in a segment-specific manner in the developing mouse hindbrain.
...
1
2
3
4
5
...