Control of the innate epithelial antimicrobial response is cell-type specific and dependent on relevant microenvironmental stimuli.

@article{Schauber2006ControlOT,
  title={Control of the innate epithelial antimicrobial response is cell-type specific and dependent on relevant microenvironmental stimuli.},
  author={Juergen Schauber and Robert A. Dorschner and Kenshi Yamasaki and Brook Brouha and Richard L Gallo},
  journal={Immunology},
  year={2006},
  volume={118 4},
  pages={509-19}
}
Immune defence against microbes depends in part on the production of antimicrobial peptides, a process that occurs in a variety of cell types but is incompletely understood. In this study, the mechanisms responsible for the induction of cathelicidin and beta-defensin antimicrobial peptides were found to be independent and specific to the cell type and stimulus. Vitamin D3 induced cathelicidin expression in keratinocytes and monocytes but not in colonic epithelial cells. Conversely, butyrate… CONTINUE READING