Control of the DNA damage checkpoint by chk1 and rad53 protein kinases through distinct mechanisms.

@article{Snchez1999ControlOT,
  title={Control of the DNA damage checkpoint by chk1 and rad53 protein kinases through distinct mechanisms.},
  author={Yolanda S{\'a}nchez S{\'a}nchez and Jeff Bachant and Haiyang Wang and Fenghua Hu and Dongfang Liu and Markus Tetzlaff and Stephen J Elledge},
  journal={Science},
  year={1999},
  volume={286 5442},
  pages={1166-71}
}
In response to DNA damage, cells activate checkpoint pathways that prevent cell cycle progression. In fission yeast and mammals, mitotic arrest in response to DNA damage requires inhibitory Cdk phosphorylation regulated by Chk1. This study indicates that Chk1 is required for function of the DNA damage checkpoint in Saccharomyces cerevisiae but acts through a distinct mechanism maintaining the abundance of Pds1, an anaphase inhibitor. Unlike other checkpoint mutants, chk1 mutants were only… CONTINUE READING
Highly Influential
This paper has highly influenced 29 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 148 extracted citations

References

Publications referenced by this paper.

All strains were congenic with Y300 except those derived from the strains provided by T

  • Plasmid, strain construction
  • Weinert (TW) as indicated and were derived with…
Highly Influential
4 Excerpts

Similar Papers

Loading similar papers…