Control of the Bacterial Cell Cycle by Cytoplasmic Growth

@article{Koch2002ControlOT,
  title={Control of the Bacterial Cell Cycle by Cytoplasmic Growth},
  author={Arthur L. Koch},
  journal={Critical Reviews in Microbiology},
  year={2002},
  volume={28},
  pages={61 - 77}
}
  • A. L. Koch
  • Published 1 January 2002
  • Biology
  • Critical Reviews in Microbiology
For free-living single-celled organisms, it can be assumed that it is their success in acquiring resources and converting them into cytoplasm that controls the timing of their cell cycles. Cytoplasm is the sink for the bulk of the environmental resources. It must be the case that this type of control must operate in dilute cultures under adequate nutrition in a constant environment. It follows that there ought to be mechanisms that measure or count the cell's biomass or some component of the… 

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References

SHOWING 1-10 OF 68 REFERENCES

What is the bacterial growth law during the division cycle?

  • S. Cooper
  • Environmental Science
    Journal of bacteriology
  • 1988
TLDR
The introduction of the static analysis of cell growth by Collins and Richmond (4) marked a new approach to the study of bacterial growth, which indicates that there is a continuously increasing rate of synthesis during the division cycle.

Coordinating DNA replication initiation with cell growth: differential roles for DnaA and SeqA proteins.

TLDR
A development of a new approach to the analysis of Escherichia coli replication control shows direct evidence that SeqA is a bona fide negative regulator of replication initiation, and implications for the complex interplay amongst growth, cell division, and DNA replication are discussed.

Attachment of the chromosome to the cell poles: the strategy for the growth of bacteria in two and three dimensions.

TLDR
A new extension of the concept that polar sites bind specifically origin and terminus DNA of the chromosome is presented that can explain how division takes place in one and then in another dimension to form two-dimensional tablets of four cells or large planar arrays.

Characterization of cell-cycle-specific events in synchronous cultures of Escherichia coli: a theoretical evaluation.

TLDR
A model was constructed of a synchronous culture of Escherichia coli cells as would be derived from a growing population immobilized on a surface, and applied to the case of one stable and one unstable cellular component, indicating that the presence of cycle-specific events may be easily detectable, but their timing and duration are very difficult to establish in synchronous growth experiments.

Autorepressor model for control of DNA replication.

TLDR
A simple feedback control system, the elements of which exist in bacteria, might answer the problem of how the rate of cell division in Escherichia coli is determined by the frequency of initiation of chromosome replication.

Regulation of the eukaryotic cell cycle: molecular antagonism, hysteresis, and irreversible transitions.

TLDR
A simple model of the antagonistic interactions between cyclin-dependent kinases and the anaphase promoting complex is presented, which shows how progress through the cell cycle can be thought of as irreversible transitions between two stable states of the regulatory system.

The initiation mess?

TLDR
This review concerns the mechanisms which control initiation of chromosome replication in enterobacteria with respect to cell growth and discusses the role of DnaA protein accumulating to a threshold level in this process.

The initiation mass for DNA replication in Escherichia coli K‐12 is dependent on growth rate.

TLDR
The initiation mass of E. coli K‐12 cells is found to increase monotonically with decreasing growth rate, indicating that the control for timing of initiation is not governed by a direct connection between mass accumulation and the molecule(s) determining initiation of replication.
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