Control of synaptic function by endocannabinoid-mediated retrograde signaling

@inproceedings{Kano2014ControlOS,
  title={Control of synaptic function by endocannabinoid-mediated retrograde signaling},
  author={Masanobu Kano},
  booktitle={Proceedings of the Japan Academy. Series B, Physical and biological sciences},
  year={2014}
}
  • Masanobu Kano
  • Published 2014 in
    Proceedings of the Japan Academy. Series B…
Since the first reports in 2001, great advances have been made towards the understanding of endocannabinoid-mediated synaptic modulation. Electrophysiological studies have revealed that one of the two major endocannabinoids, 2-arachidonoylglycerol (2-AG), is produced from membrane lipids upon postsynaptic Ca(2+) elevation and/or activation of Gq/11-coupled receptors, and released from postsynaptic neurons. The released 2-AG then acts retrogradely onto presynaptic cannabinoid CB1 receptors and… CONTINUE READING
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