Control of synapse development and plasticity by Rho GTPase regulatory proteins.

@article{Tolias2011ControlOS,
  title={Control of synapse development and plasticity by Rho GTPase regulatory proteins.},
  author={Kimberley F. Tolias and Joseph G. Duman and Kyongmi Um},
  journal={Progress in neurobiology},
  year={2011},
  volume={94 2},
  pages={133-48}
}
Synapses are specialized cell-cell contacts that mediate communication between neurons. Most excitatory synapses in the brain are housed on dendritic spines, small actin-rich protrusions extending from dendrites. During development and in response to environmental stimuli, spines undergo marked changes in shape and number thought to underlie processes like learning and memory. Improper spine development, in contrast, likely impedes information processing in the brain, since spine abnormalities… CONTINUE READING
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