Control of stem cell fate by physical interactions with the extracellular matrix.

@article{Guilak2009ControlOS,
  title={Control of stem cell fate by physical interactions with the extracellular matrix.},
  author={Farshid Guilak and Daniel Maurice Cohen and Bradley Thomas Estes and Jeffrey M. Gimble and Wolfgang B Liedtke and Christopher S. Chen},
  journal={Cell stem cell},
  year={2009},
  volume={5 1},
  pages={
          17-26
        }
}
A diverse array of environmental factors contributes to the overall control of stem cell activity. In particular, new data continue to mount on the influence of the extracellular matrix (ECM) on stem cell fate through physical interactions with cells, such as the control of cell geometry, ECM geometry/topography at the nanoscale, ECM mechanical properties, and the transmission of mechanical or other biophysical factors to the cell. Here, we review some of the physical processes by which cues… CONTINUE READING
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