Control of spontaneous and damage-induced mutagenesis by SUMO and ubiquitin conjugation

Abstract

Protein modification by ubiquitin is emerging as a signal for various biological processes in eukaryotes, including regulated proteolysis, but also for non-degradative functions such as protein localization, DNA repair and regulation of chromatin structure. A small ubiquitin-related modifier (SUMO) uses a similar conjugation system that sometimes… (More)
DOI: 10.1038/nature01965

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