Control of spoT-dependent ppGpp synthesis and degradation in Escherichia coli.

@article{Murray1996ControlOS,
  title={Control of spoT-dependent ppGpp synthesis and degradation in Escherichia coli.},
  author={Kathleen D. Murray and H. -J. Bremer},
  journal={Journal of molecular biology},
  year={1996},
  volume={259 1},
  pages={41-57}
}
Escherichia coli has two ppGpp synthetases, PSI and PSII, encoded by the relA and spoT genes. The spoT gene also encodes a ppGpp hydrolase. During exponential growth and under various starvation conditions, the level of ppGpp depends on the balance of ppGpp synthetic and degradative activities of spoT gene products. To find out how these two activities respond to different physiological conditions and to learn about the signals involved in these responses, rates of ppGpp synthesis and… CONTINUE READING