Control of specific carbon dioxide production in a fed-batch culture producing recombinant protein using a soft sensor.

Abstract

The feeding of a fed-batch cultivation producing recombinant protein was controlled by a soft sensor set-up. It was assumed that the control approach could be based on the cell's production of carbon dioxide and that this parameter indicates the metabolic state occurring at induced protein expression. The soft sensor used the on-line signals from a carbon… (More)
DOI: 10.1016/j.jbiotec.2015.02.030

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Cite this paper

@article{Gustavsson2015ControlOS, title={Control of specific carbon dioxide production in a fed-batch culture producing recombinant protein using a soft sensor.}, author={Robert Gustavsson and Cornelia Lukasser and Carl-Fredrik Mandenius}, journal={Journal of biotechnology}, year={2015}, volume={200}, pages={44-51} }