Control of spasticity in a multiple sclerosis model is mediated by CB1, not CB2, cannabinoid receptors.

@article{Pryce2007ControlOS,
  title={Control of spasticity in a multiple sclerosis model is mediated by CB1, not CB2, cannabinoid receptors.},
  author={Gareth Pryce and David Baker},
  journal={British journal of pharmacology},
  year={2007},
  volume={150 4},
  pages={519-25}
}
BACKGROUND AND PURPOSE There is increasing evidence to suggest that cannabis can ameliorate muscle-spasticity in multiple sclerosis, as was objectively shown in experimental autoimmune encephalomyelitis models. The purpose of this study was to investigate further the involvement of CB1 and CB2)cannabinoid receptors in the control of experimental spasticity. EXPERIMENTAL APPROACH Spasticity was induced in wildtype and CB1-deficient mice following the development of relapsing, experimental… CONTINUE READING

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