Control of somite patterning by Sonic hedgehog and its downstream signal response genes.

@article{Borycki1998ControlOS,
  title={Control of somite patterning by Sonic hedgehog and its downstream signal response genes.},
  author={A G Borycki and L. K. Mendham and Charles Phillips Emerson},
  journal={Development},
  year={1998},
  volume={125 4},
  pages={
          777-90
        }
}
In the avian embryo, previous work has demonstrated that the notochord provides inductive signals to activate myoD and pax1 regulatory genes, which are expressed in the dorsal and ventral somite cells that give rise to myotomal and sclerotomal lineages. Here, we present bead implantation and antisense inhibition experiments that show that Sonic hedgehog is both a sufficient and essential notochord signal molecule for myoD and pax1 activation in somites. Furthermore, we show that genes of the… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 97 CITATIONS, ESTIMATED 70% COVERAGE

Location, Location, Location: Signals in Muscle Specification

  • Journal of developmental biology
  • 2018
VIEW 16 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

The notochord: structure and functions

  • Cellular and Molecular Life Sciences
  • 2015
VIEW 5 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Fibronectin cues during somite formation

VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Regulation of myosin expression during myotome formation.

  • Development
  • 2003
VIEW 3 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Transcriptional mechanisms regulating MyoD expression in the mouse

  • Cell and Tissue Research
  • 1999
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

1998
2019

CITATION STATISTICS

  • 11 Highly Influenced Citations