Control of solid tumor growth in mice using EGF receptor-targeted RNA replicase-based plasmid DNA.

@article{Rodriguez2012ControlOS,
  title={Control of solid tumor growth in mice using EGF receptor-targeted RNA replicase-based plasmid DNA.},
  author={B. Leticia Rodriguez and Xinran Li and Kaoru Kiguchi and John Digiovanni and Evan C. Unger and Zhengrong Cui},
  journal={Nanomedicine},
  year={2012},
  volume={7 4},
  pages={475-91}
}
AIM Previously, it was shown that treatment of tumor-bearing mice with an RNA replicase-based plasmid that produces dsRNA when transfected into tumor cells significantly inhibited the tumor growth. In the present study, the feasibility of further improving the anti-tumor activity of the RNA replicase-based plasmid by targeting it into tumors cells was evaluated. MATERIAL & METHODS An EGF-conjugated, polyethylene glycosylated cationic liposome was developed to deliver the RNA replicase-based… CONTINUE READING