Control of roof plate formation by Lmx1a in the developing spinal cord.

@article{Chizhikov2004ControlOR,
  title={Control of roof plate formation by Lmx1a in the developing spinal cord.},
  author={Victor V. Chizhikov and Kathleen J. Millen},
  journal={Development},
  year={2004},
  volume={131 11},
  pages={2693-705}
}
Numerous studies have identified the roof plate as an embryonic signaling center critical for dorsal central nervous system patterning, but little is known about mechanisms that control its formation and its separation from clonally related neural crest cells and dI1 sensory interneurons. We demonstrate that the LIM homeodomain transcription factor, Lmx1a, mutated in the dreher mouse, acts to withdraw dorsal spinal cord progenitors from the cell cycle and simultaneously direct their… CONTINUE READING

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