Control of ribosomal subunit rotation by elongation factor G.

@article{Pulk2013ControlOR,
  title={Control of ribosomal subunit rotation by elongation factor G.},
  author={Arto Pulk and Jamie H D Cate},
  journal={Science},
  year={2013},
  volume={340 6140},
  pages={
          1235970
        }
}
Protein synthesis by the ribosome requires the translocation of transfer RNAs and messenger RNA by one codon after each peptide bond is formed, a reaction that requires ribosomal subunit rotation and is catalyzed by the guanosine triphosphatase (GTPase) elongation factor G (EF-G). We determined 3 angstrom resolution x-ray crystal structures of EF-G complexed with a nonhydrolyzable guanosine 5'-triphosphate (GTP) analog and bound to the Escherichia coli ribosome in different states of ribosomal… CONTINUE READING
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