Control of regulatory T cell lineage commitment and maintenance.

  title={Control of regulatory T cell lineage commitment and maintenance.},
  author={Steven Z. Josefowicz and Alexander Y Rudensky},
  volume={30 5},
Foxp3-expressing regulatory T (Treg) cells suppress pathology mediated by immune responses against self and foreign antigens and commensal microorganisms. Sustained expression of the transcription factor Foxp3, a key distinguishing feature of Treg cells, is required for their differentiation and suppressor function. In addition, Foxp3 expression prevents deviation of Treg cells into effector T cell lineages and confers dependence of Treg cell survival and expansion on growth factors, foremost… CONTINUE READING
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