Control of ras activation.

  title={Control of ras activation.},
  author={Julian Downward},
  journal={Cancer surveys},
Ras proteins are active when bound to GTP and inactive when bound to GDP: the activation state of Ras proteins is regulated by two families of proteins. GTPase activating proteins (p120GAP, neurofibromin and GAP1) are negative regulators that stimulate hydrolysis of bound GTP to GDP, and guanine nucleotide exchange factors (Sos and Ras-GRF) are positive regulators that stimulate the exchange of GDP bound to Ras for fresh GTP from the cytosol. Ras is activated in response to a wide variety of… CONTINUE READING
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