Control of pulsatile 5-HT/insulin secretion from single mouse pancreatic islets by intracellular calcium dynamics.

@article{Barbosa1998ControlOP,
  title={Control of pulsatile 5-HT/insulin secretion from single mouse pancreatic islets by intracellular calcium dynamics.},
  author={Rui M. Barbosa and Am{\'e}lia M. Silva and {\^A}ngelo R. Tom{\'e} and Jonathan A. Stamford and R. M. Santos and Luıs M. Rosario},
  journal={The Journal of physiology},
  year={1998},
  volume={510 ( Pt 1)},
  pages={135-43}
}
1. Glucose-induced insulin release from single islets of Langerhans is pulsatile. We have investigated the correlation between changes in cytosolic free calcium concentration ([Ca2+]i) and oscillatory insulin secretion from single mouse islets, in particular examining the basis for differences in secretory responses to intermediate and high glucose concentrations. Insulin release was monitored in real time through the amperometric detection of the surrogate insulin marker 5-hydroxytryptamine (5… CONTINUE READING

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