Control of pulmonary vascular smooth muscle tone by sarcoplasmic reticulum ca2+ pump blockers: thapsigargin and cyclopiazonic acid

@article{Fuente1995ControlOP,
  title={Control of pulmonary vascular smooth muscle tone by sarcoplasmic reticulum ca2+ pump blockers: thapsigargin and cyclopiazonic acid},
  author={Patrick Gonzalez De La Fuente and Jean -Pierre Savineau and Roger Marthan},
  journal={Pfl{\"u}gers Archiv},
  year={1995},
  volume={429},
  pages={617-624}
}
The effect of thapsigargin (TG) and cyclopiazonic acid (CPA) on the mechanical activity of the rat pulmonary artery were investigated. In chemically (β-escin)-skinned arterial strips, application of TG (0.1–1 μM) or CPA (0.5–10 μM) prior and throughout the loading procedure of the internal Ca2+ stores (0.3 μM free Ca2+ ions for 8–10 min) concentration dependently inhibited the subsequent contractile response induced by noradrenaline (NA, 10 μM) or caffeine (25 mM). In intact strips repeatedly… CONTINUE READING
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Ca 2§ and Sr 2§ entry induced Ca 2 § release from intracellular Ca 2 § store in smooth muscle cells of rat portal vein

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1 Excerpt

Calcium influx induced by inhibitors of the sarcoplasmic reticulum calcium-pump in vascular smooth muscle (abstract

  • P Gonzalez De La Fuente, JP Savineau, R Marthan
  • Int Union Physiol Sci, XXXII Int Congr Physiol…
  • 1993
1 Excerpt

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