Control of proton sensitivity of the NMDA receptor by RNA splicing and polyamines.

@article{Traynelis1995ControlOP,
  title={Control of proton sensitivity of the NMDA receptor by RNA splicing and polyamines.},
  author={Stephen F Traynelis and Meagan Hartley and Stephen F. Heinemann},
  journal={Science},
  year={1995},
  volume={268 5212},
  pages={873-6}
}
The function of the N-methyl-D-aspartate (NMDA)-preferring glutamate receptor can be regulated by extracellular pH, a process that may be important during ischemia in the brain or during seizures. Protons inhibit NMDA receptor function by 50 percent at pH 7.3 through interactions with the NR1 subunit, and both polyamines and NR1 exon 5 potentiate receptor function through relief of the tonic proton inhibition present at physiological pH. A single amino acid (lysine 211) was identified that… CONTINUE READING
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The function of the N - methyl - D - aspartate ( NMDA)-preferring glutamate receptor can be regulated by extracellular pH , a process that may be important during ischemia in the brain or during seizures .
The function of the N - methyl - D - aspartate ( NMDA)-preferring glutamate receptor can be regulated by extracellular pH , a process that may be important during ischemia in the brain or during seizures .
The function of the N - methyl - D - aspartate ( NMDA)-preferring glutamate receptor can be regulated by extracellular pH , a process that may be important during ischemia in the brain or during seizures .
The function of the N - methyl - D - aspartate ( NMDA)-preferring glutamate receptor can be regulated by extracellular pH , a process that may be important during ischemia in the brain or during seizures .
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