Control of protein crystal nucleation around the metastable liquid-liquid phase boundary.

  title={Control of protein crystal nucleation around the metastable liquid-liquid phase boundary.},
  author={O. M. Galkin and Peter G Vekilov},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={97 12},
The capability to enhance or suppress the nucleation of protein crystals opens opportunities in various fundamental and applied areas, including protein crystallography, production of protein crystalline pharmaceuticals, protein separation, and treatment of protein condensation diseases. Herein, we show that the rate of homogeneous nucleation of lysozyme crystals passes through a maximum in the vicinity of the liquid-liquid phase boundary hidden below the liquidus (solubility) line in the phase… CONTINUE READING

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