Control of protein and sterol trafficking by antagonistic activities of a type IV P-type ATPase and oxysterol binding protein homologue.

@article{Muthusamy2009ControlOP,
  title={Control of protein and sterol trafficking by antagonistic activities of a type IV P-type ATPase and oxysterol binding protein homologue.},
  author={Baby-Periyanayaki Muthusamy and Sumana Raychaudhuri and Paramasivam Natarajan and Fumiyoshi Abe and Ke Liu and William A Prinz and Todd R Graham},
  journal={Molecular biology of the cell},
  year={2009},
  volume={20 12},
  pages={
          2920-31
        }
}
The oxysterol binding protein homologue Kes1p has been implicated in nonvesicular sterol transport in Saccharomyces cerevisiae. Kes1p also represses formation of protein transport vesicles from the trans-Golgi network (TGN) through an unknown mechanism. Here, we show that potential phospholipid translocases in the Drs2/Dnf family (type IV P-type ATPases [P4-ATPases]) are downstream targets of Kes1p repression. Disruption of KES1 suppresses the cold-sensitive (cs) growth defect of drs2Delta… CONTINUE READING
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