Control of plasmid DNA replication by iterons: no longer paradoxical.

@article{Chattoraj2000ControlOP,
  title={Control of plasmid DNA replication by iterons: no longer paradoxical.},
  author={Dhruba K Chattoraj},
  journal={Molecular microbiology},
  year={2000},
  volume={37 3},
  pages={467-76}
}
Replication origins of a family of bacterial plasmids have multiple sites, called iterons, for binding a plasmid-specific replication initiator protein. The iteron-initiator interactions are essential for plasmid replication as well as for inhibition of plasmid over-replication. The inhibition increases with plasmid copy number and eventually shuts plasmid replication off completely. The mechanism of inhibition appears to be handcuffing, the coupling of origins via iteron-bound initiators that… CONTINUE READING